Friday 19 August 2016

evolution - Evolutionarily speaking, why do humans have 46 chromosomes


In humans, each cell normally contains 23 pairs of chromosomes, for a total of 46. Monkeys, chimpanzees, and Apes have 24 pairs (twenty-four pairs), for a total of 48.


What caused humans to have 46?



EDIT: @TomD is right, I was asking why we have one less chromosome pair than chimpanzees (for example) [23 pairs instead of 24].



Answer



I think the OP is asking why we have one less chromosome pair than chimpanzees (for example) [23 pairs instead of 24].


The is an abundance of evidence, as alluded to above by shigeta, that human chromosome 2 is the result of a telomere-to-telomere fusion of two ancestral chromosomes (IJdo et al., 1991). This event did not occur in our closest ancestors, hence we have one less chromosome pair. In fact the sequence of human chromosome 2 contains the relic of an ancestral telomere-telomere fusion (IJdo et al., 1991).


The pdf of this key reference is freely available to all from PNAS


Reference


IJdo, J.W, Baldini, A, Ward, D.C, Reeders, S.T, Wells, R.A. (1991) Origin of human chromosome 2: an ancestral telomere-telomere fusion Proc Natl Acad Sci U S A., 88 9051-9055.[pdf]


Actually it has now been shown that Neanderthals and Denisovans also exhibit the same chromosomal fusion as humans - http://m.motherjones.com/politics/2014/02/evolution-creationism-bonobos-neanderthals-denisovans-chromosome-two


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