Wednesday 14 October 2015

development - Why does cell differentiation start with the morula?


I suppose that cell differentation has to start by some external symmetry breaking. The first time there are two different types of cells is the morula with roughly 16 cells: there are some 12-15 cells forming the surface of the morula and some 1-4 cells in the interior of the morula. These are exposed to physically/chemically different local environments which might be the initial triggers of cell differentiation.


enter image description here


(source)


Questions:





  1. Is this kind of argument/picture correct?




  2. What are the significant differences in the environments of the outer and the inner blastomeres of the morula that trigger cell differentiation - and how do they do?






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