Saturday 27 July 2019

stem cells - Could fingerprints potentially be changed using a gene gun?



Not to confuse with your "DNA fingerprint" I've read surgery is readily used to not just remove but even to change people's prints through employing very small grafts between opposing hands.


About 5 years ago a Chinese group identified SMARCAD1 as a key player in the development of fingerprints. this was discovered by generating gene expression profiles of people with a very rare condition called adermatoglyphia. These people have no finger prints.


A gene gun, which uses micropartical bombardment is a technique that propels microscopic particles of heavy metals, coated with the gene of interest, "deep" into tissues.


If you were to alter the genetics of the epidermal stem cells, you could potentially permanently change the tissue that arises from those stem cells. Could this in principle work if over expression of SMARCAD1 resulted in remodeling of the prints or has other more important genes been shown since to be involved?


Do any model organisms have fingerprints, or a version thereof?


I know I'm fishing here, lots of questions. I thought it was an interesting topic and wanted to see what people here had to say.




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