Friday, 6 January 2017

human biology - Is there any advantage to one blood type over another?


All humans can be grouped into ABO and Rh+/- blood groups (at a minimum). Is there any advantage at all to one group or the other? This article hints that there are some pathogens that display a preference to a blood type (for example Schistosomiasis apparently being more common in people with blood group A, although it could be that more people have type A in the areas that the parasite inhabits). Is there any literature out there to support or refute this claim or provide similar examples?



Beyond ABO-Rh, is there any advantage or disadvantage (excluding the obvious difficulties in finding a donor after accident/trauma) in the 30 other blood type suffixes recognised by the International Society of Blood Transfusions (ISBT)?


I'd imagine not (or at least very minimal) but it would be interesting to find out if anyone knows more.



Answer



I've been doing a little more digging myself and have found a couple of other advantages:


Risk of Venous-thromboembolism (deep vein thrombosis/pulmonary embolism (1)). Blood group O individuals are at lower risk of the above conditions due to reduced levels of von Willebrand factor(2) and factor VIII clotting factors.


Cholera Infection Susceptibility & Severity. Individuals with blood group O are less susceptible to some strains of cholera (O1) but are more likely to suffer severe effects from the disease if infected (3).


E. coli Infection Susceptibility & Severity. A study in Scotland indicated that those with the O blood group showed higher than expected infection rates with E. coli O157 and significantly higher fatality rates (78.5% of fatalities had blood group O).(4)


Peptic Ulcers caused by Heliobacter pylori which can also lead to gastric cancer. Group O are again more susceptible to strains of H. pylori (5).


Whether blood group antigens are displayed on other body cells or not has been linked to increased or decreased susceptibility to many diseases, notably norrovirus and HIV. This is fully explained in the article that I was above summarising - "The relationship between blood group and disease" in addition to extended descriptions of the other two answers.


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