etiquette - Is it OK to call a professor by his first name when he/she signs emails by only first name?

If a professor in a North American country presents his- or herself by his/her first name in email messages, does this mean that students can refer to him/her by his/her first name? Or is this generally not a good idea, unless the professor has explicitly mentioned that he/she can be referred to by first name? I've noticed that most professors, who prefer to be referred to more formally, do not sign their emails with just their first names, but usually initials or first and last name.