Saturday 17 February 2018

genetics - Is HSV-vector-mediated miRNA expression in dorsal root ganglia stable?


My question is on the following article:


"Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy"


My question is, do you think the rats continued to have decreased levels of voltage-gated Na+ channels after this experiment, or did they likely gain them back up eventually, because dorsal root ganglion neurons regenerate themselves? I couldn't find this info in the article.




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