Tuesday, 25 April 2017

biophysics - How to measure Na/K channel activation at the membrane level?


Assume that there are two different signals occurring on the ECG - during depolarization and repolarization in the standard ECG. I was advised not to use the standard ECG in measuring the exact electrical events during:



  • stages 0-2

  • 3-4



We can get data about the electric activity of neurons in vivo in Fig. 1 where some data about the electric activity of neurons is present. So my thought is that a similar technique could probably work with cardiomyocytes.


Fig. 1 Example of measurement for electric activity of neurons in vivo


enter image description here


I estimate that there is about 18% uncertainty when using the standard ECG because of the peak in the stage 1 (Gibbs phenomenon) and those two complete different phases.




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