Sunday, 14 January 2018

biochemistry - What are the units of Q10 (temperature sensitivity)?



Q10 is the increase in a rate (e.g. activity of an enzyme) observed with a 10° temperature increase.


According to Wikipedia:


Q10=(R2R1)10/(T2T1)


It is apparent that the units of R (e.g. mol/g/s) cancel out, but what about the units of temperature? Does Q10 have units? It seems the units would be "per 10 °C", but it is not clear how this comes from the referenced equation



Answer



enter image description here


Figure. A schematic diagram showing the effect of the temperature on the stability of an enzyme catalysed reaction. The curves show the percentage activity remaining as the incubation period increases. From the top they represent equal increases in the incubation temperature (50 °C, 55 °C, 60 °C, 65 °C and 70 °C).


The Q10 is a unitless number, that summarizes the effect of raising temperature 10°C on the rate of a chemical reaction. A Q10 of 2.0 suggests that raising the temperature of a system by 10 °C will effectively double the rate of the reaction. This value would be expected for most chemical reactions occurring within normal physiological temperatures.


Mathematically, Q10 can be represented by the following expression:


Q10=(k2k1)10t2t1



t2 = higher temperature
k2 = rate at t2
t1 = lower temperature
k1 = rate at t1


Usually the temperature difference is about 10 °C, then you can simplify the equation


Q10=(k1k2)1010=k1k2


Edit: You can easily calculate k form Arrhenius equation


k=AeΔGRT


where k is the kinetic rate constant for the reaction, A is the Arrhenius constant, also known as the frequency factor, ΔG is the standard free energy of activation (kJ/mol) which depends on entropic and enthalpic factors, R is the gas law constant and T is the absolute temperature.


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