Monday 27 November 2017

genetics - Genotypes in diploid/haploid cells under mitotic/meotic cell divisions


I am new to genetics , and am stuck with the following question at hand:



If $2$ cells with genotypes $(A/a)$ and $(A/a,B/b)$ undergo mitotic and meotic cell divisions respectively, what will be the genotypes/gene compositions in the resultant diploid and haploid cells with respect to the above mentioned alleles?




Can someone help me how to proceed?



Answer



Though broad, here I provide a summary in graphical way.


Mitosis:


Mitosis .




MEIOSIS: 2 successive steps : Meiosis-1 and meiosis-2


Meiosis-1


Meiosis 1





Meiosis-2


meiosis-2




So lets see what happens with cells given at question.


1. Cell with genotype Aa


(monohybrid or one-point cross-experiments; that means we are looking to gene-pair at 1 loci; not looking to any other genes):


1. A. Mitosis:


Possible genotypes of their offsprings: All Aa.


1. B. Meiosis:


gametes will show 2-possibilities ; A, a.





2. Cell with genotype AaBb


(dihybrid or 2-point cross-experiments; that means we are looking on genes of 2 loci; not to any other cells):


2.A. Mitosis:


all offsprings AaBb.


2.B. Meiosis:


If given condition says the loci for A (or a) and B (or b) are on same chromosome (linked genes) and no crossing-over is there;


then We will get only 2 types of gamete AB and ab.


If crossing over(s) take place between the 2 loci; then we'll get 4 types of gamete AB, Ab, aB, ab; but their ocurring frequency will deviate from Mendel's independent assortment.


If the 2 loci are not-linked; i.e. they are located in distinct chromosome; then also we'll get 4 types of gametes AB, Ab, aB, ab; but they will follow Mendel's independent assortment pattern.




Reference:




  1. Concepts of Genetics, 8th Edition (EBook) By William Klug, Michael Cummings, Charlotte Spencer / Pearson; chapter 2 (mitosis and meiosis)




  2. The science of Genetics, 6th edition, by George Burns and Paul Bottino, Macmillan.





  3. Genetics/ P.K. Gupta/ Rastogi Publication Meerut





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