Sunday, 12 January 2020

Can proteins/peptides pass through the intestine?


I've heard somewhere said that :



Stomach cells do not absorb anything larger than single amino acids.




Is that wrong? How do biological toxins (peptides/proteins) from mushroom or bacteria like Botulinum come to our blood and affect our body after we eat them?


Update: In fact, i want to know if we drink milk, is there anyway IGF-1 protein from milk can pass through the intestine and affect our body. Because I see some arguments/debates about the IGF protein in milk can cause acne.



Answer



Entire proteins can be transported across the epithelial cells of the digestive system.https://en.wikipedia.org/wiki/Transcytosis


This is common in neonatal infants aiding in immunity passed via proteins in mother's milk. It is much less common as you age. http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/absorb_aacids.html


The process is termed "transcytosis" if you wish to search for whether this occurs for a particular substance. One such goup of proteins entering the body in this manner are prions. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004172/


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