Saturday, 10 November 2018

genetics - Are all functions of a human cell known?



Please bear with me as I'm intruding into your world from a computer science background.


In programming, once you have created a program, you know all functions of that program. Thus, 100% knowledge is achieved.


My question is, in the field of Biology, how much do we think we currently know about the human cell? Are all functions known (eg. 100%)? Are most functions known (60%)? Or do we know a miniscule proportion (1%~5%) of functions of a cell.


The reason I ask is I'm interested in the concept of simulating cells via computer. If we know about a given biological function of a cell, we could convert it into a mathematical function for use within a simulation. With simulations, you could simulate the cell's reactions to drugs, viruses, cell garbage cleanup, etc, based on it's defined functions. And the more functions we know about human cells, the better the simulation.


Thanks in advance.




Answer



As someone who has dabbled in both biology and programming, I assume you are referring to the theoritical ability of functional programming to simulate organic behaviour from well defined input. From that point of view, our comprehension of the human cell behaviour is currently near stone age level. The astounding diversity of homeostatic and signaling parameters in our body makes a realistic simulation of human cell normal behaviour largely out of reach, so don't even think about patholgic states.


The more data we will acquire, the more precise our simulations will be. Currently, our data acquisition methods are too primitive, and clearly are not deterministic enough to base computed simulations upon them.


Of course, this answer reflects my own opinion, but I dare think that most of my colleagues will adhere to that view.


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